2003 Beeson Scholars
Meredith Hawkins, MD, Albert Einstein College of Medicine: The Role of Nutrient Excess in Mediating the Insulin Resistance of Aging
Michael Irizarry, MD, Harvard Medical School/Massachusetts General Hospital: Beta-secretase and Alzheimer's Risk with Aging
Kenneth Langa, MD, PhD, University of Michigan: Long-term outcomes of Caring for a Disabled Spouse
Sarah Lisanby, MD, Columbia University College of Physicians and Surgeons: Brain Stimulation and Pharmacological Strategies to Reduce the Cognitive Side Effects of ECT in Geriatric Depression
Jack Parent, MD, University of Michigan: Stimulation of Endogenous Neural Stem Cells to Promote Recovery after Stroke
Henry Paulson, MD, PhD, University of Iowa: RNA interference (RNAi) as a Novel Therapy for Age-Related Disease
Elizabeth Phelan, MD, University of Washington: Improving Primary Care of Older Adults
Wendy Post, MD, Johns Hopkins University School of Medicine: Vascular Properties and Genetics Associated with Longevity in the Amish
Norman Sharpless, MD, University of North Carolina at Chapel Hill: The Role of the Tumor Suppressor P16 ink4a in Mammalian Aging
Michael Shlipak, MD, MPH, University of California, San Francisco: Preventing Heart Failure in Elderly Persons with Chronic Renal Insufficiency
Reisa Sperling, MD, Harvard Medical School/Brigham & Women's Hospital: Investigating the Neural Underpinnings of Memory Impairment in Aging and Early Alzheimer's Disease
2002 Beeson Scholars
David Casarett, MD, University of Pennsylvania: Improving Decision-Making About End-of-Life Care and Promoting Earlier Referral to Hospice
James Galvin, MD, Washington University School of Medicine: In Vitro and In Vivo Models of Synucleinopathies
Brad Johnson, MD, PhD, University of Pennsylvania School of Medicine: Functions of the Werner Syndrome Family of Proteins in Telomerase-Deficient Mice and Yeast
Lorraine Kyne, MD, MPH, Harvard Medical School/Beth Israel Deaconess Medical Center: Effect of Probiotic Therapy on Clinical Outcome and Immune Response to C. Difficile Infection in Elderly Patients
Albert La Spada, MD, PhD, University of Washington: Development of Therapies for Polyglutamine Neurodegeneration and Related Disorders
Michael Lin, MD, Weill Medical College of Cornell University: Mitochondrial DNA Mutations in Aging and Alzheimer’s Disease
Robert Marciniak, MD, PhD, UTHSCSA: Oxidative Stress and Telomere Maintenance: In vitro and In vivo Studies
Laura Niklason, MD, PhD, Duke University: Lifespan Extension of Vascular Cells for Tissue Engineering
Michael Schwarzschild, MD, PhD, Massachusetts General Hospital: Sorting Out Clues to Parkinson’s Disease: Caffeine, Postmenopausal Estrogen and Addiction
Jurgen Unutzer, MD, MPH, UCLA Neuropsychiatric Institute: Improving Care for Chronic Pain and Late Life Depression
2001 Beeson Scholars
Asa Abeliovich, MD, PhD, Columbia University College of Physicians and Surgeons: Molecular Analysis of the Familial Parkinson Disease Genes Parkin and Alpha-Synuclein
Katrin Andreasson, MD, Johns Hopkins University School of Medicine: Mechanisms of Cyclooxygenase-2 Dependent Neuronal Injury in Aging and Neurodegenerative Disease
Eric Coleman, MD, MPH, University of Colorado Health Science Center: Reducing Care Fragmentation Across Sites of Geriatric Care
Jay Edelberg, MD, PhD, Weill Medical College of Cornell University: Restoration of Senescent Cardiac Angiogenic Activity by Bone Marrow Transplantation
Wesley Ely, MD, MPH, FCCP, Vanderbilt University School of Medicine: The Role of Delirium and Psychoactive Drug Use on Outcomes Following Mechanical Ventilation in Older Persons
Roger Hajjar, MD, Harvard Medical School: Targeting Signaling Pathways in Aging Hearts by Gene Transfer
James Mastrianni, MD, PhD, University of Chicago School of Medicine: Aging and the Misfolded Protein: Prion Disease as a Model for Disaggregating the Aggregate
Michael Naski, MD, PhD, University of Texas Health Science Center at San Antonio: Matrix Homeostasis and Gene Expression in Aging Cartilage
Cary Reid, MD, PhD, Yale University School of Medicine: Determining the Impact of Back Pain on Physical and Social Disability Among Older Adults
Mary Whooley, MD, University of California, San Francisco, School of Medicine: Mechanisms of Association between Depression and Poor Health Outcomes in Older Patients
Kristine Yaffe, MD, University of California, San Francisco, School of Medicine: Determinants of Cognitive Change and its Outcomes in African American and White Elders
2000 Beeson Scholars
Brock Beamer, MD, Johns Hopkins University School of Medicine: Genetic variations in PPAR- and RxR: Effects on Body Composition and Metabolism in Older Adults
Gunnar Gouras, MD, Weill College of Medicine of Cornell University: Neuronal A-beta Accumulation: Aging and Oxidative Stress
Mary Beth Hamel, MD, MPH, Harvard Medical School: Decision Making and Outcomes for Elderly Patients with Surgical Problems
Joshua Hare, MD, Johns Hopkins University School of Medicine: The Role of Nitric Oxide in Aging-Related Cardiovascular Adaptions
Fuki Hisama, MD, Yale University School of Medicine: The Molecular Basis of Aging in Werner Syndrome
Jason Karlawish, MD, University of Pennsylvania School of Medicine: Caregiver and Patient Preferences for the Treatment of Alzheimer's Disease
Jean Kutner, MD, MSPH., University of Colorado Health Science Center: Symptom Management at the End of Life: Decreasing Distress and Improving Quality of Life
Brett Lauring, MD, PhD, Columbia University College of Physician and Surgeons: An In- Vitro Assay for Gamma Secretase Processing of the Amyloid Precursor Protein
Frank Lee, MD, PhD, University of Pennsylvania School of Medicine: Protein Kinases and Alzheimer's Disease
R. Sean Morrison, MD, Mount Sinai School of Medicine: Interventions to Improve Pain Outcomes
Scott Small, MD, Columbia University College of Physician & Surgeons: Functional Analysis of the Hippocampal Formation in Age-Related Memory Decline
1999 Beeson Scholars
Jeanne Anderson, MD, University of Texas Health Science Center at San Antonio: Clinical Trials in Age-Associated Leukemia and Leukemia-Related Diseases with Correlative Studies of Clonality and Functional Status
Kenneth Covinsky, MD, MPH, University of California, San Francisco: Outcomes of Frail Nursing Home-Eligible Elders Living in the Community
Matthew Frosch, MD, PhD, Harvard Medical School: Estrogen, Aging and Alzheimer's Disease Mechanisms and Model Systems
Daniel Laskowitz, MD, Duke University Medical Center: Apolipoprotein E, Microglial Activation, and Neurodegenerative Disease
Dale Leitman, MD, PhD, University of California, San Francisco: Role of Coactivators in Estrogen Repression of Gene Transcription
Richard Lin, MD, University of Texas Health Science Center at San Antonio: The Role of Oxidative Stress in Aging Effects on Vascular Smooth Muscle Cell Growth and Signal Transduction
David Lynch, MD, PhD, University of Pennsylvania: Excitotoxicity in Neurodegenerative Disorders: New Understanding from NMDA Receptor Subtypes
Edward Marcantonio, MD, Harvard Medical School: Reducing Delirium in Post-Acute Care: An Interventional Trial
Mitchell Nobler, MD, Columbia University College of Physicians and Surgeons: Serotonin and PET Neuroimaging in Normal Aging and Geriatric Depression
Anne Louise Oaklander, MD, PhD, Harvard Medical School: Cellular Mechanisms of Chronic Neuropathic Pain
Thomas Rando, MD, PhD, Stanford University School of Medicine:
Mechanisms of Age-Related Muscle Atrophy: The Role of Cellular Antioxidant Defenses
1998 Beeson Scholars
Helene Benveniste, MD, PhD, Duke University Medical Center: In Vivo Magnetic Resonance Microscopy and Alzheimer's Disease: Defining and Staging the Progression of Alzheimer's Pathology in Transgenic Mice Overexpressing Beta Amyloid Protein
Laura Dugan, MD, Washington University School of Medicine: Mechanisms of Neuroprotection by C60 Derivatives: Relevance to Oxidative Stress during Aging
Terri Fried, MD, Yale University School of Medicine: A Longitudinal Study of Terminally Ill Patient's Preference for Care
Anne Kenny, MD, University of Connecticut Health Center: Mechanisms of Bone Loss in Older Men with Low Testosterone Levels
Alison Moore, MD, MPH, UCLA School of Medicine: Screening for Harmful and Hazardous Drinking in Older Persons
Thomas Perls, MD, Harvard Medical School: Familiality of Extreme Longevity and Mitochondrial Longevity-Assurance Genes in Centenarian Subjects
Eric Peterson, MD, Duke University Medical Center: Toward a Rational Use of Revascularization in the Aged
R. Scott Turner, MD, PhD, University of Michigan Medical School: The Role of X11a in Amyloid Precursor Protein
Jeremy Walston, MD, Johns Hopkins University School of Medicine: Molecular Etiologies of Age-Related Changes in Body Composition
Raymond Yung, MD, University of Michigan Medical School: Lymphocyte Homing in Aging
1997 Beeson Scholars
Nir Y. Barzilai, MD, Albert Einstein College of Medicine: The Effect of Age-Dependent Increase in Visceral Fat on Insulin Action and Secretion
Michele F. Bellantoni, MD, Johns Hopkins University School of Medicine: Growth Hormone and Sex Steroid Effects on Bone in Older Women
James R. Burke, MD, PhD, Duke University Medical Center: Polyglutamine Proteins as a Model System for Studying Protein Aggregation and Cell Death in Aging and Neurodegenerative Disease
Mark T. D'Esposito, MD, University of Pennsylvania School of Medicine: Functional Neuroimaging Studies of Working Memory in Normal Human Aging
Thomas M. Gill, MD, Yale University School of Medicine: Identifying the Events That Precipitate Functional Dependence Among Community-living Elderly Persons
Bernard F. Godley, MD, PhD, University of Texas Medical Branch: Role of Oxidative DNA Damage and Repair in Age-Related Macular Degeneration
Todd E. Golde, MD, PhD, Mayo Clinic Jacksonville, Mayo Medical School: Proteolytic Generation of the Amyloid b Peptide in Alzheimer's Disease
Helen Hoenig, MD, MPH, Duke University Medical Center: An Investigation of the Physical Costs and the Quality-of-Life Benefits of Wheelchairs for Older Persons
Elan D. Louis, MD, College of Physicians & Surgeons of Columbia University: Functional Correlates of Essential Tremor
Charles A. Thornton, MD, University of Rochester School of Medicine: Pathophysiology of Myotonic Dystrophy, a Progeroid Syndrome
1996 Beeson Scholars
Christopher M. Callahan, MD, Indiana University School of Medicine: The Use of Percutaneous Endoscopic Gastrostomy among Older Adults in a Community Setting
Robert W. Doms, MD, PhD, University of Pennsylvania: STM2, APP, and Alzheimer's disease
P. Murali Doraiswamy, MD, Duke University Medical Center: Apolipoprotein E type 4 Allele and Cerebral Metabolism in Relatives at Risk for Familial Alzheimer's Disease
Harlan M. Krumholz, MD, Yale University School of Medicine: Clinical Spectrum, Treatment and Outcome of Elderly Congestive Heart Failure Patients
Makau Lee, MD, PhD, University of Mississippi Medical Center: Studies on Aging, Dietary Restriction and Gastric Mucosal Defense
Richard F. Loeser, Jr., MD, Rush Medical College: Growth Factors and Aging in Cartilage
Karen M. Prestwood, MD, University of Connecticut Health Center: Bone Turnover and the Response to Estrogen in Older Caucasian, Hispanic and African American Postmenopausal Women
May J. Reed, MD, University of Washington School of Medicine: Angiogenesis, the Extracellular Matrix, and Wound Repair in Aging
Robert G. Smith, MD, PhD, Baylor College of Medicine: Role of Voltage-Gated Calcium Channel Autoantibodies in Motoneuron Injury in ALS
1995 Beeson Scholars
Ashley Bush, MB, BS, DPM, PhD, Harvard Medical School: Zinc Exposure as a Risk Factor for Alzheimer's Disease
Ted M. Dawson, MD, PhD, Johns Hopkins University School of Medicine: Gene Therapy for Neurologic Disorders
David M. Holtzman, MD, Washington University School of Medicine: Use of Animal Models and Neuronal Cell Lines to Study Alzheimer's-like Neurodegeneration
Edward H. Koo, MD, University of California, San Diego School of Medicine: The mechanism of amyloid beta-protein (AB) production from the amyloid precursor protein (APP) in neurons
Mark S. Lachs, MD, MPH, Cornell University Medical College: The Morbidity and Mortality of Elder Abuse
Frank M. Longo, MD, PhD, University of California, San Francisco School of Medicine: New Strategies for Treating Neurodegenerative Disease
Richard A. Marottoli, MD, MPH, Yale University School of Medicine: Older Driver Assessment: A Multilevel Approach
Lina M. Obeid, MD, Medical University of South Carolina: Lipid Signal Transduction in Cellular Senescence
Peter Reaven, MD, University of California, San Diego School of Medicine: The Relationship of Aging and Antioxidant Defense Systems to Artherosclerosis
Alan R. Shuldiner, MD, University of Maryland School of Medicine: Genetics of Diabetes and Obesity in the Elderly